The number of lesions ablated increases risk of intrahepatic recurrence but does not impact overall survival.īoyle P, Ferlay J: Cancer incidence and mortality in Europe, 2004. ConclusionĬombined resection and ablation is associated with long-term-survival in a subset of patients however, recurrence is common. Survival was not influenced by the number of lesions resected or ablated (both p > 0.05). While total number of lesions treated (hazard ratio (HR) = 1.47, p = 0.23) and number of lesions resected (HR = 1.18, p = 0.43) did not impact risk of intrahepatic recurrence, the number of lesions ablated did (HR = 1.36, p = 0.05). At last follow-up, 84 patients (67%) recurred with a median disease-free interval of 15 months.
The median number of lesions resected was 4 the median number of lesions ablated was 1. Patients presented with a median of six lesions. Of these, 125 patients underwent resection combined with ablation as the primary mode of treatment. Methodsīetween 19, 1,425 patients who underwent surgery for CRLM were queried from an international multi-institutional database. We sought to determine the efficacy of combined resection and ablation for CRLM.
By combining resection and ablation, the number of patients eligible for surgery can be expanded. Only 10–25% of patients presenting with colorectal liver metastases (CRLM) are amenable to hepatic resection.
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